Organic Letters·· 19 小时前AI 评分34
手性 BINOL 衍生双羟基聚醚/KF 催化体系经对称性破缺不对称消除构建轴手性环己亚基
Catalytic Construction of Axially Chiral Cyclohexylidenes through Symmetry-Breaking Asymmetric Elimination
AI 导读
手性 BINOL 衍生双羟基聚醚/KF 催化体系实现了前手性 β-磺酰基酮的对称性破缺不对称 β-消除，通过立体生成性 C=C 键形成将分子对称性直接转化为轴手性，获得一系列轴手性环己亚基，产率中等至优异、对映选择性高至优异。产物经还原、环氧化和溴化反应验证了合成实用性。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Organic Letters · doi.org
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