Small·· 4 小时前AI 评分38
自激活一氧化氮纳米发生器通过调控内源性铜代谢诱导铜死亡以增强抗PD-L1阻断治疗
Self‐Activated Nitric Oxide Nanogenerators Induce Cuproptosis via Regulating the Endogenous Copper Metabolism for Anti‐PD‐L1 Blockade Therapy
AI 导读
研究提出“NO诱导铜死亡”策略：纳米材料产生的NO通过抑制铜伴侣蛋白CCS表达触发内源性Cu⁺释放，从而诱导铜死亡。据此设计的无铜自激活NO纳米发生器AZORHP由Arg稳定的过氧化锌（AZO）、沉默MT2A的siRNA及透明质酸-多肽（HP）构成，HP上修饰抗PD-L1肽与MMP-2可切割连接子。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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