Angewandte Chemie International Edition·· 16 小时前精选AI 评分62
用阳离子稳定取代基调控自消除连接子的1,6-消除释放速率
Engineering Rapid Payload Release Rate in 1,6‐Elimination Processes of Self‐Immolative Linkers
AI 导读
研究提出通过引入阳离子稳定取代基来调控自消除连接子（SIL）的载荷释放速率，速率常数相比参比SIL最多提升10⁴倍。DFT计算的离子对中间体稳定性与自消除一级速率常数呈强相关，为这一策略提供了理性设计依据。
推荐理由
通过阳离子稳定取代基把自消除连接子的释放速率常数提高最多10⁴倍，并用DFT离子对稳定性与一级速率常数的相关性给出设计依据。
创新点
把阳离子稳定取代基引入SIL设计，并用DFT离子对稳定性与速率常数的定量关联建立可预测的速率调控依据，同时指出偶联物亲脂性这一此前被忽视的速率因素。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Angewandte Chemie International Edition · doi.org
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