Advanced Materials·· 5 小时前精选AI 评分60
动态硬化水凝胶微生理系统揭示视网膜基质硬化经 FAK 通路导致血管失稳
A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization
AI 导读
研究团队构建了包埋周细胞—内皮毛细血管网络的 iPSC 微生理系统（MPS），用可动态硬化的水凝胶在无高糖暴露条件下复现视网膜基质硬化。
推荐理由
作者用可动态变硬的 iPSC 水凝胶微生理系统，把视网膜基质硬化与周细胞丢失、血管失稳联系起来，并给出 FAK 这一可干预靶点。
创新点
该工作把可动态硬化的水凝胶与 iPSC 来源的周细胞—内皮毛细血管网络结合，在无高糖条件下单独考察基质硬化对血管稳定性的作用，并将 FAK 依赖的力转导确定为可干预靶点。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Materials · doi.org
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