Advanced Functional Materials·· 11 小时前精选AI 评分58
靶向脂质-聚合物杂化纳米粒递送基因编码 TRIM21 降解子实现可编程蛋白降解
Targeted Lipid–Polymer Nanoparticles Enable Gene‐Encoded TRIM21 Degraders for Programmable Protein Degradation
AI 导读
研究团队构建了基于靶向脂质-聚合物杂化纳米粒的基因编码可编程蛋白降解平台，通过系统调控聚(β-氨基酯)纳米载体并整合阳离子脂质与转铁蛋白受体靶向配体，实现编码 E3 连接酶融合蛋白质粒的高效胞质递送。
推荐理由
该平台用靶向脂质-聚合物杂化纳米粒递送编码降解子的质粒，为体内蛋白降解提供了一条不改造靶基因的递送路线。
创新点
将基因编码降解子与靶向脂质-聚合物杂化纳米粒结合，绕开 Trim-Away 技术对预成型抗体或重组蛋白递送的依赖，并可在不改动内源靶基因的前提下实现体内可编程降解。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Functional Materials · doi.org
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