Advanced Science·· 8 小时前AI 评分40
可输注脱细胞细胞外基质材料通过固有亲和力与生物活性信号结合梗死心肌血管并诱导促修复基因表达
An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling
AI 导读
将可输注脱细胞细胞外基质（iECM）分为高分子量与低分子量组分后发现，高分子量纳米纤维组分sGAG含量更高、在流动条件下与ECM蛋白和细胞表面受体结合效率更高，低分子量球状组分则驱动血管通透性降低。两种组分单独均无法达到完整iECM的梗死区滞留水平，说明二者在梗死定位上相互依赖、对iECM整体功能均不可或缺。单核RNA测序显示两组分诱导相当的免疫调节与促修复转录谱，提示组成相似性可能驱动转录响应。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Science · doi.org
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