Organic Letters·· 9 小时前AI 评分10
Xylarimides A 与 B：含 3-呋喃-2-羟基丙酸单元的 21 元环状酯肽靶向 ATG7 诱导肾癌细胞致死性自噬
Xylarimides A and B, Unusual 21 Membered Cyclic Depsipeptides Featuring a 3-Furan-2-Hydroxypropionic Acid Unit, Target ATG7 to Induce Lethal Autophagy in Renal Cancer Cells
AI 导读
从真菌 Xylaria striata 中分离出 Xylarimides A 和 B 两个含此前未报道的 3-呋喃-2-羟基丙酸单元的 21 元环状酯肽。Xylarimide A 强效抑制肾癌细胞系增殖及小鼠模型 786-O 异种移植瘤生长，机制上通过直接靶向核心蛋白 ATG7 激活自噬流并抑制 AKT-mTOR 信号，诱导致死性自噬。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Organic Letters · doi.org
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