Biomacromolecules·· 13 小时前AI 评分48
可喷涂海藻酸钠水凝胶介导超声透皮给药治疗痛风性关节炎
Sprayable Hydrogel-Mediated Ultrasound Transdermal Drug Delivery for Gouty Arthritis Treatment
AI 导读
一种超声辅助可喷涂水凝胶通过海藻酸钠（SA）与Ca²⁺快速离子交联形成载秋水仙碱储库，替代传统耦合剂并实现局部持续释药。超声增强透皮渗透并加速释药，治疗后残留水凝胶继续维持释放。在体内该平台可减轻关节肿胀、抑制炎症细胞因子、保护骨结构并改善痛风性关节炎的运动功能。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Biomacromolecules · doi.org
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