Small·· 7 小时前AI 评分50
酶活性颗粒基质用于骨样矿化的芯片建模
Engineering an Enzymatically Active Granular Matrix for On‐Chip Modeling of Bone‐Like Mineralization
AI 导读
将碱性磷酸酶（ALP）经硫醇–烯光化学共价偶联到PEG微凝胶上，24 h后保留逾90%初始活性，单分散微凝胶在芯片上组装成堵塞态可灌流基质，实现酶负载与底物供给的独立调控。该系统在24–48 h内原位矿化，生成缺钙、低结晶度的磷灰石类早期骨矿物相，矿物空间分布取决于灌流方式。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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