Advanced Functional Materials·· 6 小时前AI 评分38
靶向 ALOX15 的 ROS 响应脂质纳米颗粒 rLNP@siALOX15-5 治疗过敏性结膜炎及其共病干眼症
Targeting ALOX15 with a ROS‐Responsive Lipid Nanoparticle for the Treatment of Allergic Conjunctivitis and Its Comorbidity Dry Eye Disease
AI 导读
设计出负载 siALOX15-5 的 ROS 响应脂质纳米颗粒 rLNP@siALOX15-5，通过增强眼部渗透并持续沉默 ALOX15，同时抑制炎症相关信号通路与脂质过氧化。在自身免疫相关干眼症小鼠模型中，该颗粒缓解临床症状并恢复眼表稳态。在过敏性结膜炎与干眼症共病模型中，其疗效优于环孢素 A 和 TobraDex 单药治疗，达到两者联合用药的相当效果。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Functional Materials · doi.org
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