Small·· 18 小时前AI 评分38
磁性凋亡小体负载三嵌段水凝胶增强胞葬作用促进透明软骨再生
A Magnetic Apoptotic Body‐Loaded Triblock Hydrogel Amplifies Efferocytosis for Hyaline Cartilage Regeneration
AI 导读
将超顺磁性Fe3O4纳米棒锚定于中性粒细胞凋亡小体构建FP-NAB，并负载于可注射温敏水凝胶PFN中，实现关节腔内持续释放与原位滞留。外部磁场刺激下，PFN在体外增强巨噬细胞胞葬作用、抑制M1极化并提升抗炎信号。大鼠骨软骨缺损模型中，PFN重塑滑膜微环境、招募内源性骨髓干细胞并促进纤维软骨透明化，使修复转向透明软骨再生。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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