Journal of the American Chemical Society·· 12 小时前AI 评分38
糖胺聚糖通过多价、pH 依赖相互作用促进淀粉样β蛋白聚集
Glycosaminoglycans Promote Amyloid-β Aggregation via Multivalent, pH-Dependent Interactions
AI 导读
糖胺聚糖（GAGs）作为 pH 响应性静电支架，在弱酸性、早期内体样条件下选择性加速 Aβ(1–42) 聚集，中性 pH 下则无此效应。质子化的 N 端组氨酸是 GAG 结合的关键决定因素，GAG 与 Aβ 带电荷 N 端区域的弱相互作用促使肽链靠近并暴露邻近的疏水聚集倾向片段。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Journal of the American Chemical Society · doi.org
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