ACS Nano·· 13 小时前精选AI 评分58
细胞内 PISA 构建肽纳米片用于炎性乳腺癌治疗
Intracellular Polymerization-Induced Self-Assembly of Peptide Nanosheets for Inflammatory Breast Cancer Therapy
AI 导读
研究报道了一种细胞内聚合诱导自组装（PISA）策略，在 365 nm UV 照射下由光引发剂 I2959 引发 HisMAm 在炎性乳腺癌（IBC）细胞内自组装成肽纳米片。
推荐理由
在细胞内原位构建肽纳米片，同时抑制迁移侵袭并诱导副凋亡，为局部治疗提供材料学思路。
创新点
把 PISA 从体外制备搬到细胞内原位进行，用光控时空定位生成力学活性肽纳米片，将细胞骨架物理干预与内质网应激副凋亡两条通路叠加。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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