Angewandte Chemie International Edition·· 16 小时前精选AI 评分58
P–CHD–TPP 探针经酶触发原位自组装实现 PANoptosis 光动力免疫治疗
Enzymatic In Situ Self‐Assembly of a Fluorogenic Photosensitizer Induces PANoptosis for Photodynamic‐Immunotherapy
AI 导读
作者报道了 P–CHD–TPP 探针，在碱性磷酸酶（ALP）触发脱磷酸后自组装为带 TPP 与 CHD 基团的荧光纳米颗粒，优先蓄积于线粒体。
推荐理由
作者用酶触发原位自组装把线粒体损伤与免疫激活串成一条链，读者可看到一种不依赖 PANoptosome 组装的光动力免疫治疗路线。
创新点
以 CHD 基团共价标记次磺酰化蛋白来关闭内源 ROS 清除系统，从而绕开 PANoptosome 组装的上游信号要求，用持续线粒体损伤触发 PANoptosis。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Angewandte Chemie International Edition · doi.org
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