ACS Nano·· 5 小时前AI 评分33
人尿液来源诱导多能干细胞膜实现黑色素瘤个性化透皮纳米治疗
Human Urine–Derived Induced Pluripotent Stem Cell Membranes Enable Personalized Transdermal Nanotherapy for Melanoma
AI 导读
一种整合了尿液来源诱导多能干细胞（iPSC）膜包覆MnO2纳米颗粒（MNPs）的水凝胶透皮贴片，可实现黑色素瘤的个性化透皮纳米治疗。患者来源的iPSC膜通过CXCR4/CXCL12轴增强肿瘤靶向与免疫逃逸，MNPs在肿瘤微环境中实现pH响应性细胞毒药物释放。该贴片可无创直接递送至皮肤病灶，延长药物暴露并有望提升患者依从性。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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