Advanced Science·· 18 小时前AI 评分30
生命早期聚乙烯微塑料暴露经 PI3K/AKT1/Nrf2 信号加重小鼠 ADHD 样行为：来自试点队列与多组学分析的证据
Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses
AI 导读
90 名儿童队列中，PE 是血液中检出最多的聚合物，且在 ADHD 患儿中丰度更高，PE 负荷越高症状越重、IL-6 升高、抗氧化能力下降。多组学与网络分析共同指向 PI3K/AKT1/Nrf2 信号；围产期尼古丁小鼠模型中发育期 PE 共暴露加重 ADHD 样行为、多巴胺能功能障碍与氧化损伤，褪黑素可部分缓解，而 AAV 介导的 PI3K 敲低削弱其保护作用。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Science · doi.org
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