ACS Nano·· 12 小时前精选AI 评分58
炎症响应水凝胶经TREM2靶向小胶质细胞递送Eupatilin脂质体促进脊髓损伤修复
An Inflammation-Responsive Hydrogel with Targeted Microglial Delivery of Eupatilin-Loaded Liposomes Orchestrates Immunomodulation for Spinal Cord Injury Repair
AI 导读
研究团队构建了FlipE@GelMA/HAPBA（FGH）炎症响应平台，将FTY720修饰的Eupatilin脂质体（FlipE）负载于GelMA/HAPBA的3D生物打印纤维水凝胶中。
推荐理由
该平台把炎症响应释药与TREM2靶向小胶质细胞结合起来，为脊髓损伤局部免疫调节提供了一条可借鉴的递送设计思路。
创新点
将炎症响应性硼酸酯断裂释药与FTY720介导的TREM2受体靶向结合在同一3D生物打印纤维水凝胶中，实现对病灶小胶质细胞的选择性递送与表型重编程。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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