Small·· 8 小时前AI 评分40
PHB 纳米颗粒通过控释 β-羟基丁酸酯改善脓毒症免疫麻痹与预后
Poly‐β‐Hydroxybutyrate Nanoparticles Improve Septic Immunoparalysis and Prognosis by Energy‐Refreshing via Controlled Release of β‐Hydroxybutyrate
AI 导读
采用乳液-溶剂蒸发法制备的可生物降解聚-β-羟基丁酸酯纳米颗粒（PHB NPs）通过持续释放 β-羟基丁酸酯（BHB），在脓毒症小鼠体内改善免疫麻痹、提高存活率并恢复对 LPS 再攻击的免疫应答，同时保留存活动物的认知功能。机制上，BHB 经 TCA–OXPHOS 轴恢复免疫麻痹细胞的生物能量代谢。小队列脓毒症患者外周血单核细胞的离体实验重现了上述保护效应。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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