ACS Nano·· 12 小时前精选AI 评分58
膜环境筛选获得P1肽，修饰PEG–PCL胶束提升三阴性乳腺癌靶向递送
Membrane-Context Screening Identifies a Functionally Active Peptide for Targeted Nanodelivery in Triple-Negative Breast Cancer
AI 导读
研究团队用BT-549细胞膜功能化二氧化硅微球建立膜环境筛选策略，从7-mer组合库中选出P1（KFYVSGT）肽。P1偶联到PEG–PCL胶束后保持粒径、电荷、形貌、稳定性和载药量不变，使BT-549细胞摄取提高约5倍、BT-549异种移植模型肿瘤蓄积提高约3倍；载多柔比星时肿瘤体积增至初始的1.96倍，非靶向胶束为4.83倍，并显示初步全身耐受性良好。
推荐理由
作者用细胞膜功能化微球筛选肽配体，把筛选条件与纳米载体递送活性直接挂钩，为靶向配体筛选提供了一条可迁移的路线。
创新点
筛选不再只看配体与受体的结合强弱，而是以细胞膜功能化固定相保留配体，使筛出的P1在偶联PEG–PCL胶束后仍保留纳米递送活性。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
%20Microsoft%20Corporation.%20Permission%20is%20hereby%20granted,%20free%20of%20charge,%20to%20any%20person%20obtaining%20a%20copy%20of%20this%20software%20and%20associated%20documentation%20files%20(the%20'Software'),%20to%20deal%20in%20the%20Software%20without%20restriction,%20including%20without%20limitation%20the%20rights%20to%20use,%20copy,%20modify,%20merge,%20publish,%20distribute,%20sublicense,%20and/or%20sell%20copies%20of%20the%20Software,%20and%20to%20permit%20persons%20to%20whom%20the%20Software%20is%20furnished%20to%20do%20so,%20subject%20to%20the%20following%20conditions:%20The%20above%20copyright%20notice%20and%20this%20permission%20notice%20shall%20be%20included%20in%20all%20copies%20or%20substantial%20portions%20of%20the%20Software.%20THE%20SOFTWARE%20IS%20PROVIDED%20'AS%20IS',%20WITHOUT%20WARRANTY%20OF%20ANY%20KIND,%20EXPRESS%20OR%20IMPLIED,%20INCLUDING%20BUT%20NOT%20LIMITED%20TO%20THE%20WARRANTIES%20OF%20MERCHANTABILITY,%20FITNESS%20FOR%20A%20PARTICULAR%20PURPOSE%20AND%20NONINFRINGEMENT.%20IN%20NO%20EVENT%20SHALL%20THE%20AUTHORS%20OR%20COPYRIGHT%20HOLDERS%20BE%20LIABLE%20FOR%20ANY%20CLAIM,%20DAMAGES%20OR%20OTHER%20LIABILITY,%20WHETHER%20IN%20AN%20ACTION%20OF%20CONTRACT,%20TORT%20OR%20OTHERWISE,%20ARISING%20FROM,%20OUT%20OF%20OR%20IN%20CONNECTION%20WITH%20THE%20SOFTWARE%20OR%20THE%20USE%20OR%20OTHER%20DEALINGS%20IN%20THE%20SOFTWARE%20--%3e%3csvg%20width='32'%20height='32'%20viewBox='0%200%2032%2032'%20fill='none'%20xmlns='http://www.w3.org/2000/svg'%3e%3cpath%20d='M12.8472%203.83391C12.9336%202.79732%2013.8001%202%2014.8403%202H17.1597C18.1999%202%2019.0664%202.79732%2019.1528%203.83391L19.3882%206.6587C19.422%207.06373%2019.8992%207.2614%2020.2095%206.99887L22.3734%205.16789C23.1674%204.49599%2024.3439%204.54493%2025.0795%205.28045L26.7196%206.92056C27.4551%207.65608%2027.504%208.8326%2026.8321%209.62666L25.0012%2011.7905C24.7386%2012.1008%2024.9363%2012.578%2025.3413%2012.6118L28.1661%2012.8472C29.2027%2012.9336%2030%2013.8001%2030%2014.8403V17.1597C30%2018.1999%2029.2027%2019.0664%2028.1661%2019.1528L25.3413%2019.3882C24.9363%2019.422%2024.7386%2019.8992%2025.0012%2020.2095L26.8321%2022.3733C27.504%2023.1674%2027.4551%2024.3439%2026.7196%2025.0794L25.0795%2026.7196C24.3439%2027.4551%2023.1674%2027.504%2022.3734%2026.8321L20.2095%2025.0011C19.8992%2024.7386%2019.422%2024.9363%2019.3882%2025.3413L19.1528%2028.1661C19.0664%2029.2027%2018.1999%2030%2017.1597%2030H14.8403C13.8001%2030%2012.9336%2029.2027%2012.8472%2028.1661L12.6118%2025.3413C12.578%2024.9363%2012.1008%2024.7386%2011.7905%2025.0012L9.62666%2026.8321C8.8326%2027.504%207.65608%2027.4551%206.92056%2026.7196L5.28045%2025.0795C4.54493%2024.3439%204.496%2023.1674%205.16789%2022.3734L6.99888%2020.2095C7.26141%2019.8992%207.06373%2019.422%206.65871%2019.3882L3.83391%2019.1528C2.79732%2019.0664%202%2018.1999%202%2017.1597V14.8403C2%2013.8001%202.79732%2012.9336%203.83391%2012.8472L6.65871%2012.6118C7.06373%2012.578%207.2614%2012.1008%206.99888%2011.7905L5.16789%209.62664C4.496%208.83258%204.54493%207.65606%205.28045%206.92054L6.92056%205.28043C7.65608%204.54491%208.8326%204.49597%209.62666%205.16787L11.7905%206.99884C12.1008%207.26137%2012.578%207.06369%2012.6118%206.65867L12.8472%203.83391ZM21%2016C21%2013.2386%2018.7614%2011%2016%2011C13.2386%2011%2011%2013.2386%2011%2016C11%2018.7614%2013.2386%2021%2016%2021C18.7614%2021%2021%2018.7614%2021%2016Z'%20fill='%23B4ACBC'/%3e%3cpath%20d='M24%2016C24%2020.4183%2020.4183%2024%2016%2024C11.5817%2024%208%2020.4183%208%2016C8%2011.5817%2011.5817%208%2016%208C20.4183%208%2024%2011.5817%2024%2016ZM20.5%2016C20.5%2013.5147%2018.4853%2011.5%2016%2011.5C13.5147%2011.5%2011.5%2013.5147%2011.5%2016C11.5%2018.4853%2013.5147%2020.5%2016%2020.5C18.4853%2020.5%2020.5%2018.4853%2020.5%2016Z'%20fill='%23998EA4'/%3e%3cpath%20d='M10.5%2016C10.5%2012.9624%2012.9624%2010.5%2016%2010.5C19.0376%2010.5%2021.5%2012.9624%2021.5%2016C21.5%2019.0376%2019.0376%2021.5%2016%2021.5C12.9624%2021.5%2010.5%2019.0376%2010.5%2016ZM21%2016C21%2013.2386%2018.7614%2011%2016%2011C13.2386%2011%2011%2013.2386%2011%2016C11%2018.7614%2013.2386%2021%2016%2021C18.7614%2021%2021%2018.7614%2021%2016Z'%20fill='%23CDC4D6'/%3e%3c/svg%3e){kind=small}
%20Microsoft%20Corporation.%20Permission%20is%20hereby%20granted,%20free%20of%20charge,%20to%20any%20person%20obtaining%20a%20copy%20of%20this%20software%20and%20associated%20documentation%20files%20(the%20'Software'),%20to%20deal%20in%20the%20Software%20without%20restriction,%20including%20without%20limitation%20the%20rights%20to%20use,%20copy,%20modify,%20merge,%20publish,%20distribute,%20sublicense,%20and/or%20sell%20copies%20of%20the%20Software,%20and%20to%20permit%20persons%20to%20whom%20the%20Software%20is%20furnished%20to%20do%20so,%20subject%20to%20the%20following%20conditions:%20The%20above%20copyright%20notice%20and%20this%20permission%20notice%20shall%20be%20included%20in%20all%20copies%20or%20substantial%20portions%20of%20the%20Software.%20THE%20SOFTWARE%20IS%20PROVIDED%20'AS%20IS',%20WITHOUT%20WARRANTY%20OF%20ANY%20KIND,%20EXPRESS%20OR%20IMPLIED,%20INCLUDING%20BUT%20NOT%20LIMITED%20TO%20THE%20WARRANTIES%20OF%20MERCHANTABILITY,%20FITNESS%20FOR%20A%20PARTICULAR%20PURPOSE%20AND%20NONINFRINGEMENT.%20IN%20NO%20EVENT%20SHALL%20THE%20AUTHORS%20OR%20COPYRIGHT%20HOLDERS%20BE%20LIABLE%20FOR%20ANY%20CLAIM,%20DAMAGES%20OR%20OTHER%20LIABILITY,%20WHETHER%20IN%20AN%20ACTION%20OF%20CONTRACT,%20TORT%20OR%20OTHERWISE,%20ARISING%20FROM,%20OUT%20OF%20OR%20IN%20CONNECTION%20WITH%20THE%20SOFTWARE%20OR%20THE%20USE%20OR%20OTHER%20DEALINGS%20IN%20THE%20SOFTWARE%20--%3e%3csvg%20width='32'%20height='32'%20viewBox='0%200%2032%2032'%20fill='none'%20xmlns='http://www.w3.org/2000/svg'%3e%3cpath%20d='M4.17488%2028.0659L3.93406%2027.8251C1.35531%2025.2464%201.35531%2021.022%203.93406%2018.4333L6.27291%2016.0944L14.0776%2014.4555L16.0978%206.26952L18.4333%203.93406C21.012%201.35531%2025.2363%201.35531%2027.8251%203.93406L28.0659%204.17488C30.6447%206.75363%2030.6447%2010.978%2028.0659%2013.5667L25.7355%2015.8972L17.8981%2017.93L15.9157%2025.717L13.5667%2028.0659C10.988%2030.6447%206.75363%2030.6447%204.17488%2028.0659Z'%20fill='%2326C9FC'/%3e%3cpath%20d='M22.5%206C22.7761%206%2023%205.77614%2023%205.5C23%205.22386%2022.7761%205%2022.5%205C22.2239%205%2022%205.22386%2022%205.5C22%205.77614%2022.2239%206%2022.5%206Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M20.5%208C20.7761%208%2021%207.77614%2021%207.5C21%207.22386%2020.7761%207%2020.5%207C20.2239%207%2020%207.22386%2020%207.5C20%207.77614%2020.2239%208%2020.5%208Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M22.5%2010C22.7761%2010%2023%209.77614%2023%209.5C23%209.22386%2022.7761%209%2022.5%209C22.2239%209%2022%209.22386%2022%209.5C22%209.77614%2022.2239%2010%2022.5%2010Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M25%2011.5C25%2011.7761%2024.7761%2012%2024.5%2012C24.2239%2012%2024%2011.7761%2024%2011.5C24%2011.2239%2024.2239%2011%2024.5%2011C24.7761%2011%2025%2011.2239%2025%2011.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M25%207.5C25%207.77614%2024.7761%208%2024.5%208C24.2239%208%2024%207.77614%2024%207.5C24%207.22386%2024.2239%207%2024.5%207C24.7761%207%2025%207.22386%2025%207.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M26.5%2010C26.7761%2010%2027%209.77614%2027%209.5C27%209.22386%2026.7761%209%2026.5%209C26.2239%209%2026%209.22386%2026%209.5C26%209.77614%2026.2239%2010%2026.5%2010Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M6%2022.5C6%2022.7761%205.77614%2023%205.5%2023C5.22386%2023%205%2022.7761%205%2022.5C5%2022.2239%205.22386%2022%205.5%2022C5.77614%2022%206%2022.2239%206%2022.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M7.5%2025C7.77614%2025%208%2024.7761%208%2024.5C8%2024.2239%207.77614%2024%207.5%2024C7.22386%2024%207%2024.2239%207%2024.5C7%2024.7761%207.22386%2025%207.5%2025Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M10%2026.5C10%2026.7761%209.77614%2027%209.5%2027C9.22386%2027%209%2026.7761%209%2026.5C9%2026.2239%209.22386%2026%209.5%2026C9.77614%2026%2010%2026.2239%2010%2026.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M7.5%2021C7.77614%2021%208%2020.7761%208%2020.5C8%2020.2239%207.77614%2020%207.5%2020C7.22386%2020%207%2020.2239%207%2020.5C7%2020.7761%207.22386%2021%207.5%2021Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M10%2022.5C10%2022.7761%209.77614%2023%209.5%2023C9.22386%2023%209%2022.7761%209%2022.5C9%2022.2239%209.22386%2022%209.5%2022C9.77614%2022%2010%2022.2239%2010%2022.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M11.5%2025C11.7761%2025%2012%2024.7761%2012%2024.5C12%2024.2239%2011.7761%2024%2011.5%2024C11.2239%2024%2011%2024.2239%2011%2024.5C11%2024.7761%2011.2239%2025%2011.5%2025Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M25.7548%2015.8553L16.1382%206.23865L6.25833%2016.1185L15.875%2025.7352L25.7548%2015.8553Z'%20fill='%2300A6ED'/%3e%3c/svg%3e){kind=small}
%20Microsoft%20Corporation.%20Permission%20is%20hereby%20granted,%20free%20of%20charge,%20to%20any%20person%20obtaining%20a%20copy%20of%20this%20software%20and%20associated%20documentation%20files%20(the%20'Software'),%20to%20deal%20in%20the%20Software%20without%20restriction,%20including%20without%20limitation%20the%20rights%20to%20use,%20copy,%20modify,%20merge,%20publish,%20distribute,%20sublicense,%20and/or%20sell%20copies%20of%20the%20Software,%20and%20to%20permit%20persons%20to%20whom%20the%20Software%20is%20furnished%20to%20do%20so,%20subject%20to%20the%20following%20conditions:%20The%20above%20copyright%20notice%20and%20this%20permission%20notice%20shall%20be%20included%20in%20all%20copies%20or%20substantial%20portions%20of%20the%20Software.%20THE%20SOFTWARE%20IS%20PROVIDED%20'AS%20IS',%20WITHOUT%20WARRANTY%20OF%20ANY%20KIND,%20EXPRESS%20OR%20IMPLIED,%20INCLUDING%20BUT%20NOT%20LIMITED%20TO%20THE%20WARRANTIES%20OF%20MERCHANTABILITY,%20FITNESS%20FOR%20A%20PARTICULAR%20PURPOSE%20AND%20NONINFRINGEMENT.%20IN%20NO%20EVENT%20SHALL%20THE%20AUTHORS%20OR%20COPYRIGHT%20HOLDERS%20BE%20LIABLE%20FOR%20ANY%20CLAIM,%20DAMAGES%20OR%20OTHER%20LIABILITY,%20WHETHER%20IN%20AN%20ACTION%20OF%20CONTRACT,%20TORT%20OR%20OTHERWISE,%20ARISING%20FROM,%20OUT%20OF%20OR%20IN%20CONNECTION%20WITH%20THE%20SOFTWARE%20OR%20THE%20USE%20OR%20OTHER%20DEALINGS%20IN%20THE%20SOFTWARE%20--%3e%3csvg%20width='32'%20height='32'%20viewBox='0%200%2032%2032'%20fill='none'%20xmlns='http://www.w3.org/2000/svg'%3e%3cpath%20d='M3%2013C3%2018.5228%207.47715%2023%2013%2023C18.5228%2023%2023%2018.5228%2023%2013C23%207.47715%2018.5228%203%2013%203C7.47715%203%203%207.47715%203%2013Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M18.3481%207.73205C18.9004%208.68864%2018.7665%209.79989%2018.049%2010.2141C17.3316%2010.6283%2016.3023%2010.1886%2015.75%209.23205C15.1977%208.27547%2015.3316%207.16421%2016.049%206.75C16.7665%206.33579%2017.7958%206.77547%2018.3481%207.73205Z'%20fill='white'/%3e%3cpath%20d='M2%2013C2%2019.0751%206.92487%2024%2013%2024C15.2952%2024%2017.4262%2023.2971%2019.1895%2022.0947C18.9147%2023.3086%2019.2498%2024.6327%2020.195%2025.5779L23.3769%2028.7599C24.8414%2030.2243%2027.2158%2030.2243%2028.6803%2028.7599C30.1447%2027.2954%2030.1447%2024.921%2028.6803%2023.4566L25.4983%2020.2746C24.5607%2019.3371%2023.2503%2018.9997%2022.0445%2019.2626C23.2774%2017.4852%2024%2015.327%2024%2013C24%206.92487%2019.0751%202%2013%202C6.92487%202%202%206.92487%202%2013ZM22%2013C22%2017.9706%2017.9706%2022%2013%2022C8.02944%2022%204%2017.9706%204%2013C4%208.02944%208.02944%204%2013%204C17.9706%204%2022%208.02944%2022%2013Z'%20fill='%23533566'/%3e%3c/svg%3e){kind=small}