Advanced Science·· 10 小时前精选AI 评分58
相序编程微针贴片 QR/AB-MNs 分阶段释放氢气与槲皮素促进烧伤创面少瘢痕愈合
Phase‐Programmed Microneedles Enable Sequential Hydrogen and Quercetin Release for Scar‐Reduced Regeneration of Burn Wounds
AI 导读
研究报道了一种相序编程微针贴片 QR/AB-MNs，由包载槲皮素（QR）的 PLGA 壳层与负载释氢前药氨硼烷（AB）的磺丁基醚-β-环糊精（SBECD）核层构成，可在轻度酸性创面微环境中先持续释放氢气并降解 AB 产物，随后随 PLGA 逐步降解延长 QR 释放。
推荐理由
该微针贴片用 PLGA 壳与 SBECD 核实现氢气与槲皮素的分阶段释放，为感染性烧伤创面提供感染控制与抗纤维化并行的时序方案。
创新点
把释氢前药与抗纤维化药物分置于核壳两层，借创面酸性环境与 PLGA 降解速率形成先抗菌抗氧化、后抑制成纤维细胞增殖与胶原沉积的时序释放，而非同步给药。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Science · doi.org
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