Science Advances·· 9 小时前精选AI 评分78
晶态三维膜实现天然产物无色谱纯化，紫杉醇截留约96%并富集四倍
Crystalline three-dimensional membranes enable chromatography-free purification of natural products
AI 导读
研究团队用晶态三维膜通过有机溶剂纳滤实现复杂天然产物混合物的无色谱纯化，在商业红豆杉粗提物上连续运行6天，紫杉醇截留约96%、富集四倍，同时允许有价值的前体透过。膜在甲醇中溶胀可忽略，可稳定进行分子筛分；通过纳米球组装界面聚合可大面积制备连续晶态膜。生命周期评估显示其碳排放比液相色谱降低近一个数量级。
推荐理由
原文给出紫杉醇纯化中约96%截留与四倍富集、连续运行6天的数据，可据此判断膜法替代色谱的可行性。
创新点
以刚性、纳米力学稳健的晶态通道在有机溶剂中保持抗溶胀的分子筛分，用膜法替代天然产物药物纯化中的色谱步骤，并给出连续运行与碳排放对比数据。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Science Advances · doi.org
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