Advanced Functional Materials·· 18 小时前精选AI 评分58
谷氨酰胺修饰脂质纳米颗粒经关节腔递送 FGF18 mRNA 缓解骨关节炎软骨退变
Glutamine‐Modified Ionizable Lipid Nanoparticles Deliver FGF18‐mRNA to Alleviate Cartilage Degeneration in Osteoarthritis
AI 导读
研究团队开发了谷氨酰胺修饰的可电离脂质纳米颗粒（GLNP），用于关节腔内递送 FGF18 mRNA。GLNP 粒径均一、多分散指数良好，可实现 RNA 完全包封并防止降解；相比未修饰 LNP，它实现了高效溶酶体逃逸、深层软骨渗透和增强的软骨细胞摄取。
推荐理由
谷氨酰胺修饰的脂质纳米颗粒把 FGF18 mRNA 送进软骨深层，为骨关节炎的核酸递送提供了一个可借鉴的载体设计思路。
创新点
在可电离脂质纳米颗粒表面引入谷氨酰胺，把软骨深层渗透、软骨细胞亲和与谷氨酰胺的代谢调节合并到同一递送体系中，用于 FGF18 mRNA 的关节腔内递送。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Functional Materials · doi.org
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