Journal of the American Chemical Society·· 12 小时前AI 评分18
分支型四特异性纳米抗体通过蛋白–聚糖免疫检查点协同调控重编程肿瘤糖免疫界面
A Branched Tetraspecific Nanobody Reprograms the Tumor Glyco-Immune Interface through Coupled Protein–Glycan Checkpoint Modulation
AI 导读
一种分支型四特异性纳米抗体经 SpyTag/SpyCatcher 介导的生物正交连接，将唾液酸酶模块、anti-CTLA-4 与 anti-PD-L1 纳米抗体及药代动力学延长结构域化学整合为四臂分支大分子框架，可同时实现蛋白检查点阻断与肿瘤细胞、免疫细胞表面的局部糖萼重塑。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Journal of the American Chemical Society · doi.org
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