Nature Materials· Anna Demming·· 1 天前AI 评分32
脂质纳米颗粒如何随 mRNA 药物崛起而主导递送
Lipid nanoparticles call the shots as mRNA medicine takes off
AI 导读
mRNA 的治疗潜力被关注数十年，直到与脂质纳米颗粒研究结合才成为现实。研究人员正寻求提高疗效并减少副作用的方法，以将这类递送载体的应用从疫苗拓展至肺部与神经干预。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Nature Materials · nature.com
%20Microsoft%20Corporation.%20Permission%20is%20hereby%20granted,%20free%20of%20charge,%20to%20any%20person%20obtaining%20a%20copy%20of%20this%20software%20and%20associated%20documentation%20files%20(the%20'Software'),%20to%20deal%20in%20the%20Software%20without%20restriction,%20including%20without%20limitation%20the%20rights%20to%20use,%20copy,%20modify,%20merge,%20publish,%20distribute,%20sublicense,%20and/or%20sell%20copies%20of%20the%20Software,%20and%20to%20permit%20persons%20to%20whom%20the%20Software%20is%20furnished%20to%20do%20so,%20subject%20to%20the%20following%20conditions:%20The%20above%20copyright%20notice%20and%20this%20permission%20notice%20shall%20be%20included%20in%20all%20copies%20or%20substantial%20portions%20of%20the%20Software.%20THE%20SOFTWARE%20IS%20PROVIDED%20'AS%20IS',%20WITHOUT%20WARRANTY%20OF%20ANY%20KIND,%20EXPRESS%20OR%20IMPLIED,%20INCLUDING%20BUT%20NOT%20LIMITED%20TO%20THE%20WARRANTIES%20OF%20MERCHANTABILITY,%20FITNESS%20FOR%20A%20PARTICULAR%20PURPOSE%20AND%20NONINFRINGEMENT.%20IN%20NO%20EVENT%20SHALL%20THE%20AUTHORS%20OR%20COPYRIGHT%20HOLDERS%20BE%20LIABLE%20FOR%20ANY%20CLAIM,%20DAMAGES%20OR%20OTHER%20LIABILITY,%20WHETHER%20IN%20AN%20ACTION%20OF%20CONTRACT,%20TORT%20OR%20OTHERWISE,%20ARISING%20FROM,%20OUT%20OF%20OR%20IN%20CONNECTION%20WITH%20THE%20SOFTWARE%20OR%20THE%20USE%20OR%20OTHER%20DEALINGS%20IN%20THE%20SOFTWARE%20--%3e%3csvg%20width='32'%20height='32'%20viewBox='0%200%2032%2032'%20fill='none'%20xmlns='http://www.w3.org/2000/svg'%3e%3cpath%20fill-rule='evenodd'%20clip-rule='evenodd'%20d='M16%208.05051C16.6353%207.40223%2017.5207%207%2018.5%207H26.5C27.2428%207%2027.8892%207.40449%2028.234%208.00326C28.3036%208.12402%2028.3296%208.26363%2028.3296%208.40297V10.6972L29%2025.5C29%2026.8807%2027.8807%2028%2026.5%2028H5.5C4.11929%2028%203%2026.8807%203%2025.5L3.67038%2010.6972V8.40298C3.67038%208.26363%203.69643%208.12402%203.76597%208.00327C4.11082%207.40451%204.75724%207%205.5%207H13.5C14.4793%207%2015.3647%207.40223%2016%208.05051Z'%20fill='%23B4ACBC'/%3e%3cpath%20d='M17.7324%2030H28.4989C29.3295%2030%2030%2029.3221%2030%2028.4948V27.4414C30%2026.614%2029.3295%2025%2028.4989%2025H3.50107C2.67048%2025%202%2026.614%202%2027.4414V28.5047C2%2029.3321%202.67048%2030%203.50107%2030H14.2676C14.6134%2030.5978%2015.2597%2031%2016%2031C16.7403%2031%2017.3866%2030.5978%2017.7324%2030Z'%20fill='%230074BA'/%3e%3cpath%20fill-rule='evenodd'%20clip-rule='evenodd'%20d='M3.50107%2010H14V11H18V10H28.4989C29.3295%2010%2030%2010.6679%2030%2011.4953V27.4948C30%2028.3221%2029.3295%2029%2028.4989%2029H17.7324C17.3866%2029.5978%2016.7403%2030%2016%2030C15.2597%2030%2014.6134%2029.5978%2014.2676%2029H3.50107C2.67048%2029%202%2028.3321%202%2027.5047V11.4953C2%2010.6679%202.67048%2010%203.50107%2010ZM17.5%2027.5C17.5%2028.3284%2016.8284%2029%2016%2029C15.1716%2029%2014.5%2028.3284%2014.5%2027.5C14.5%2026.6716%2015.1716%2026%2016%2026C16.8284%2026%2017.5%2026.6716%2017.5%2027.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M13%208H5.80278C5.30125%208%204.8329%208.25065%204.5547%208.66795L3%2011V25.5C3%2026.3284%203.67157%2027%204.5%2027H27.5C28.3284%2027%2029%2026.3284%2029%2025.5V11L27.4453%208.66795C27.1671%208.25065%2026.6988%208%2026.1972%208H19V11H13V8Z'%20fill='%23B4ACBC'/%3e%3cpath%20d='M5.5%208H13.5C14.8807%208%2016%209.11929%2016%2010.5V27L15.5528%2026.1056C15.214%2025.428%2014.5215%2025%2013.7639%2025H5.5C4.94772%2025%204.5%2024.5523%204.5%2024V9C4.5%208.44772%204.94772%208%205.5%208Z'%20fill='%23F3EEF8'/%3e%3cpath%20d='M18.5%208H26.5C27.0523%208%2027.5%208.44772%2027.5%209V24C27.5%2024.5523%2027.0523%2025%2026.5%2025H18.2361C17.516%2025%2016.8546%2025.3867%2016.5%2026.007V8.99976C16.9561%208.39267%2017.6822%208%2018.5%208Z'%20fill='%23F3EEF8'/%3e%3c/svg%3e){kind=small}
%20Microsoft%20Corporation.%20Permission%20is%20hereby%20granted,%20free%20of%20charge,%20to%20any%20person%20obtaining%20a%20copy%20of%20this%20software%20and%20associated%20documentation%20files%20(the%20'Software'),%20to%20deal%20in%20the%20Software%20without%20restriction,%20including%20without%20limitation%20the%20rights%20to%20use,%20copy,%20modify,%20merge,%20publish,%20distribute,%20sublicense,%20and/or%20sell%20copies%20of%20the%20Software,%20and%20to%20permit%20persons%20to%20whom%20the%20Software%20is%20furnished%20to%20do%20so,%20subject%20to%20the%20following%20conditions:%20The%20above%20copyright%20notice%20and%20this%20permission%20notice%20shall%20be%20included%20in%20all%20copies%20or%20substantial%20portions%20of%20the%20Software.%20THE%20SOFTWARE%20IS%20PROVIDED%20'AS%20IS',%20WITHOUT%20WARRANTY%20OF%20ANY%20KIND,%20EXPRESS%20OR%20IMPLIED,%20INCLUDING%20BUT%20NOT%20LIMITED%20TO%20THE%20WARRANTIES%20OF%20MERCHANTABILITY,%20FITNESS%20FOR%20A%20PARTICULAR%20PURPOSE%20AND%20NONINFRINGEMENT.%20IN%20NO%20EVENT%20SHALL%20THE%20AUTHORS%20OR%20COPYRIGHT%20HOLDERS%20BE%20LIABLE%20FOR%20ANY%20CLAIM,%20DAMAGES%20OR%20OTHER%20LIABILITY,%20WHETHER%20IN%20AN%20ACTION%20OF%20CONTRACT,%20TORT%20OR%20OTHERWISE,%20ARISING%20FROM,%20OUT%20OF%20OR%20IN%20CONNECTION%20WITH%20THE%20SOFTWARE%20OR%20THE%20USE%20OR%20OTHER%20DEALINGS%20IN%20THE%20SOFTWARE%20--%3e%3csvg%20width='32'%20height='32'%20viewBox='0%200%2032%2032'%20fill='none'%20xmlns='http://www.w3.org/2000/svg'%3e%3cpath%20d='M4.17488%2028.0659L3.93406%2027.8251C1.35531%2025.2464%201.35531%2021.022%203.93406%2018.4333L6.27291%2016.0944L14.0776%2014.4555L16.0978%206.26952L18.4333%203.93406C21.012%201.35531%2025.2363%201.35531%2027.8251%203.93406L28.0659%204.17488C30.6447%206.75363%2030.6447%2010.978%2028.0659%2013.5667L25.7355%2015.8972L17.8981%2017.93L15.9157%2025.717L13.5667%2028.0659C10.988%2030.6447%206.75363%2030.6447%204.17488%2028.0659Z'%20fill='%2326C9FC'/%3e%3cpath%20d='M22.5%206C22.7761%206%2023%205.77614%2023%205.5C23%205.22386%2022.7761%205%2022.5%205C22.2239%205%2022%205.22386%2022%205.5C22%205.77614%2022.2239%206%2022.5%206Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M20.5%208C20.7761%208%2021%207.77614%2021%207.5C21%207.22386%2020.7761%207%2020.5%207C20.2239%207%2020%207.22386%2020%207.5C20%207.77614%2020.2239%208%2020.5%208Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M22.5%2010C22.7761%2010%2023%209.77614%2023%209.5C23%209.22386%2022.7761%209%2022.5%209C22.2239%209%2022%209.22386%2022%209.5C22%209.77614%2022.2239%2010%2022.5%2010Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M25%2011.5C25%2011.7761%2024.7761%2012%2024.5%2012C24.2239%2012%2024%2011.7761%2024%2011.5C24%2011.2239%2024.2239%2011%2024.5%2011C24.7761%2011%2025%2011.2239%2025%2011.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M25%207.5C25%207.77614%2024.7761%208%2024.5%208C24.2239%208%2024%207.77614%2024%207.5C24%207.22386%2024.2239%207%2024.5%207C24.7761%207%2025%207.22386%2025%207.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M26.5%2010C26.7761%2010%2027%209.77614%2027%209.5C27%209.22386%2026.7761%209%2026.5%209C26.2239%209%2026%209.22386%2026%209.5C26%209.77614%2026.2239%2010%2026.5%2010Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M6%2022.5C6%2022.7761%205.77614%2023%205.5%2023C5.22386%2023%205%2022.7761%205%2022.5C5%2022.2239%205.22386%2022%205.5%2022C5.77614%2022%206%2022.2239%206%2022.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M7.5%2025C7.77614%2025%208%2024.7761%208%2024.5C8%2024.2239%207.77614%2024%207.5%2024C7.22386%2024%207%2024.2239%207%2024.5C7%2024.7761%207.22386%2025%207.5%2025Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M10%2026.5C10%2026.7761%209.77614%2027%209.5%2027C9.22386%2027%209%2026.7761%209%2026.5C9%2026.2239%209.22386%2026%209.5%2026C9.77614%2026%2010%2026.2239%2010%2026.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M7.5%2021C7.77614%2021%208%2020.7761%208%2020.5C8%2020.2239%207.77614%2020%207.5%2020C7.22386%2020%207%2020.2239%207%2020.5C7%2020.7761%207.22386%2021%207.5%2021Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M10%2022.5C10%2022.7761%209.77614%2023%209.5%2023C9.22386%2023%209%2022.7761%209%2022.5C9%2022.2239%209.22386%2022%209.5%2022C9.77614%2022%2010%2022.2239%2010%2022.5Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M11.5%2025C11.7761%2025%2012%2024.7761%2012%2024.5C12%2024.2239%2011.7761%2024%2011.5%2024C11.2239%2024%2011%2024.2239%2011%2024.5C11%2024.7761%2011.2239%2025%2011.5%2025Z'%20fill='%2300A6ED'/%3e%3cpath%20d='M25.7548%2015.8553L16.1382%206.23865L6.25833%2016.1185L15.875%2025.7352L25.7548%2015.8553Z'%20fill='%2300A6ED'/%3e%3c/svg%3e){kind=small}