Advanced Materials·· 14 小时前AI 评分35
镧系/过渡金属离子配位纳米结构消除“激活-抵抗”限制以增强铜死亡与肿瘤免疫治疗
“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy
AI 导读
La-Cu@Lap/IWR-1 纳米颗粒通过 La³⁺ 配位增强 Cu²⁺ 的多重酶模拟活性并破坏溶酶体酸化，提高铜离子可利用度。联合拉帕替尼（Lap）缓解 MEMO1 对 Cu²⁺ 的屏蔽，释放的 Wnt 抑制剂 IWR-1 抑制铜死亡诱导中激活的 Wnt/β-catenin 通路并与 Lap 协同下调 HIF-1α，消除铜死亡抵抗。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Materials · doi.org
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