Journal of the American Chemical Society·· 11 小时前精选AI 评分62
马来酰亚胺与肼在生理条件下反应，构建动态腙交联水凝胶
Facile Maleimide-Hydrazine Reaction to Form Stable Bonds in Dynamic Hydrazone-Cross-Linked Hydrogels
AI 导读
研究在 pH = 7.4、37 °C 下实现肼与醛、马来酰亚胺的一锅反应，同时形成动态腙键和稳定的肼基琥珀酰亚胺键。以 PEG 和透明质酸（HA）功能化大分子单体成胶时，马来酰亚胺与含胺基团在烷基肼存在下经 aza-Michael 加成反应最快，肼基琥珀酰亚胺交联的稳定性高于烷基腙和苄基腙交联。
推荐理由
原文在生理条件下用马来酰亚胺与肼一锅生成动态腙键和稳定肼基琥珀酰亚胺键，并给出交联结构与细胞迁移的对应关系。
创新点
在生理条件下让马来酰亚胺同时与肼和醛反应，一锅得到动态腙键与稳定肼基琥珀酰亚胺键两类交联，使动态腙水凝胶在需要稳定性的场景中也能使用。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Journal of the American Chemical Society · doi.org
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