Small·· 8 小时前AI 评分26
用于组织工程与再生医学中 mRNA 递送时空控制的生物材料平台：设计规则、治疗应用与转化路线图
Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap
AI 导读
这篇综述系统评估了用于 mRNA 时空可控递送的纳米载体、宏观储库与支架，以及分级纳米复合与刺激响应体系。文章提出连接 mRNA 化学与材料性质同递送、表达、免疫应答及组织修复的“货物–靶点–时序”框架，并考察了肌肉骨骼、心血管、神经、皮肤与内脏组织中的证据。综述还评估了关键质量属性、纵向监测、制造、储存、给药与安全性，并给出分阶段转化路线图及 AI 赋能的个性化设计策略。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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