ACS Nano·· 7 小时前精选AI 评分60
天冬氨酸-紫杉醇偶联前药通过DSPE-PEG2k调控自组装形貌并在乳腺癌治疗中比较纤维、棒状与球形效果
Morphology-Tunable Nanoparticles of Aspartic Acid Paclitaxel Conjugates for Breast Cancer Treatment
AI 导读
研究者将天冬氨酸经琥珀酰连接臂与紫杉醇偶联得到前药PCA，PCA可自组装成纳米纤维；加入DSPE-PEG2k后形貌由纤维转为棒状、最终转为球形。分子动力学模拟显示，分子间氢键从DP1纳米纤维的约50个降至DP3纳米颗粒的不足5个，天冬氨酸中羧基相关原子占总氢键的53.24%。
推荐理由
原文给出氢键数量随形貌变化的模拟数据，读者可据此理解前药自组装形貌的调控路径。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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