Advanced Science·· 6 小时前精选AI 评分58
Dman-C11 超分子两亲分子实现 MRSA 触发解组装与成像清除
MRSA‐Triggered Disassembly of an Immune‐Recruiting NIR Probe for Bacterial Imaging and Clearance
AI 导读
研究报道了一种免疫招募型超分子两亲分子 Dman-C11，由半花菁 NIR 荧光团、D-甘露糖胺免疫招募基元和疏水 C11 链构成，在水中自组装成纳米颗粒并因聚集导致猝灭（ACQ）而荧光被抑制。
推荐理由
该探针把 MRSA 膜触发解组装、20 倍荧光开启与光动力杀菌、免疫招募整合到单一分子上，可供抗菌诊疗一体化设计参考。
创新点
将膜触发超分子解组装与 ACQ 荧光开启、光动力杀菌和免疫细胞招募集成于单一分子，使细菌识别、激活成像与宿主辅助清除在同一探针上联动。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Science · doi.org
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