ACS Macro Letters·· 3 小时前精选AI 评分60
p(Glu-b-GTA) 双嵌段共聚物通过嵌段比调控实现对耐药革兰阴性菌的选择性杀灭
Precise Engineering Poly(Glucose Acrylate)- b -Poly(Guanidine Thioctic Acid) Diblock Copolymers for Selective Killing of Drug-Resistant Gram-negative Bacteria
AI 导读
研究以RAFT聚合结合硫醇引发的二硫交换聚合构建了聚（葡萄糖丙烯酸酯）-b-聚（胍基硫辛酸）双嵌段共聚物 p(Glum-b-GTAn)，可精确调控糖基与胍基嵌段比。
推荐理由
通过RAFT与硫醇引发的二硫交换聚合精确调控糖基与胍基嵌段比例，读者可看到嵌段比对杀菌活性与溶血、细胞相容性的平衡关系。
创新点
用可控聚合把天然多糖难以避免的分子量分布问题绕开，以合成糖基嵌段替代糖侧基的无规引入，使糖基与胍基嵌段比可精确调节，从而在保留胍基聚合物膜活性杀菌的同时降低非特异性细胞毒性。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Macro Letters · doi.org
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