Small·· 7 小时前AI 评分38
超声响应核壳微球实现氢气介导氧化还原预适应与KGN诱导软骨再生治疗骨关节炎
Spatiotemporal Core–Shell Microspheres Enable Hydrogen‐Mediated Redox Priming and Kartogenin‐Induced Cartilage Regeneration for Osteoarthritis Bio‐Rescue
AI 导读
一种经微流控制备的超声响应核壳微球平台被用于骨关节炎治疗：PLGA核载kartogenin（KGN），海藻酸钠壳层富集二硫化锡（SnS）纳米片。关节内注射后超声触发SnS原位产生低浓度H₂，清除过量活性氧、恢复氧化还原稳态并促使滑膜巨噬细胞向M2表型极化。在大鼠OA模型中，该平台持续释放KGN逆转细胞外基质代谢失衡，阻止关节退变并保留软骨组织完整性。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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