ACS Nano·· 5 小时前AI 评分42
二氧化锰纳米酶整合取向纳米纤维通过Gas6介导成纤维细胞-巨噬细胞通讯促进糖尿病创面修复
Manganese Dioxide Nanozyme-Integrated Aligned Nanofibers Promote Diabetic Wound Repair through Growth Arrest-Specific Protein 6-Mediated Fibroblast-to-Macrophage Communication
AI 导读
一种由甲基丙烯酰化明胶与邻硝基苄基修饰明胶制成、负载MnO₂纳米酶的取向电纺纳米纤维膜，在水合与短时紫外照射后形成贴合创面的纳米纤维水凝胶。180 μg/mL MnO₂配方可降低细胞内ROS并促进成纤维细胞增殖、迁移及内皮血管生成，其机制为成纤维细胞分泌Gas6以抑制炎症型巨噬细胞反应、增强修复型巨噬细胞反应。在链脲佐菌素诱导糖尿病小鼠中，该水凝胶加速创面闭合并增强血管化、再上皮化与胶原重塑。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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