Science Advances·· 7 小时前精选AI 评分58
键选择性 SRS 成像揭示临床来源微纳塑料的摄取期代谢应激
Clinically derived micro- and nanoplastic uptake drives spatiotemporally confined metabolic stress revealed by bond-selective imaging
AI 导读
研究用化学键选择性受激拉曼散射（SRS）显微与可分离持续暴露和胞内滞留的细胞模型，直接观察临床来源微/纳塑料（MP/NP）与细胞的相互作用。细胞应激主要发生在 MP/NP 暴露期间，并伴随脂滴（LD）组成改变；细胞外去除后，胞内滞留的 MP/NP 基本呈惰性，脂质代谢与细胞功能恢复。
推荐理由
用键选择性 SRS 成像把 MP/NP 的细胞损伤定位到摄取阶段而非长期胞内滞留，为毒性评估提供时间分辨视角。
创新点
把损伤的时间窗口从长期胞内累积前移到摄取过程本身，并用 SRS 成像在亚细胞尺度上捕捉到邻近脂滴中短暂的 AA 富集。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Science Advances · doi.org
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