Journal of the American Chemical Society·· 12 小时前精选AI 评分58
JACS：肟基萘二酰亚胺实现细菌还原性可视化分级与NIR-II光热抗菌
Establishing Oxime as a Bioresponsive Group on Naphthalene Diimide: Visual Bacterial Classification and NIR-II Photothermal Antibacterial
AI 导读
研究者设计肟基萘二酰亚胺（NONDI），首次证明肟基可作为生物响应基团：细菌将肟基还原为亚胺基，NONDI 完全转化为 NHNDI，机理上该还原触发肟基 N–O 键均裂并释放羟基自由基。NONDI 可逐步还原为 NHNDI、NHNDI•– 和 NHNDI2–，依细菌还原性由弱到强呈现四种不同颜色，从而实现细菌的可视化分级；NHNDI•– 的强 NIR-II 吸收还赋予其光热抗菌性能。
推荐理由
原文给出肟基被细菌还原为亚胺基的机理与四色响应，读者可据此判断这类响应基团用于细菌分级的可行性。
创新点
首次把肟基确立为可在还原条件下响应的生物响应基团，并利用其多步还原产生的四色变化把细菌还原能力转成可读信号，同时借 NHNDI•– 的 NIR-II 吸收叠加光热抗菌功能。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Journal of the American Chemical Society · doi.org
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