ACS Nano·· 8 小时前AI 评分40
仿“特洛伊木马”纳米陷阱 MIPGPX4@aMOF@CM 以 GSH 响应分子门控实现铁释放与空间 GPX4 抑制协同的铁死亡
A Trojan Horse Nanotrap with a GSH-Responsive Molecular Gate Orchestrates Ferroptosis via Coupled Iron Release and Spatial GPX4 Inhibition
AI 导读
研究构建了仿“特洛伊木马”纳米陷阱 MIPGPX4@aMOF@CM，内核为选择性识别 GPX4 的分子印迹聚合物（MIP），外壳为铁基非晶 MOF（aMOF）并包覆癌细胞膜。胞内高 GSH 触发 aMOF 降解，实现 GSH 消耗、铁释放与印迹 GPX4 结合位点的按需暴露。该门控级联协同促进 Fenton 化学与 GPX4 失活，增强肿瘤选择性铁死亡响应。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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