Journal of the American Chemical Society·· 8 小时前精选AI 评分58
无金属胶束纳米反应器实现CO持续释放并短暂调控TLR4炎症信号
Carbon Monoxide-Releasing Nanoreactors Transiently Modulate TLR4 Signaling to Resolve Inflammation
AI 导读
研究报道了一种无金属胶束纳米反应器，在内过氧化物（EPO）与3-羟基黄酮（3-HF）衍生物之间构建纳米限域级联反应，实现CO持续释放。EPO热分解持续产生单线态氧（1O2），氧化邻近的CO前体释放CO，分子筛选显示级联动力学受EPO结构及3-HF芳环延伸和硫族取代调控，氧化速率可调范围达3个数量级。
推荐理由
原文给出内过氧化物与3-HF结构如何调控CO释放动力学，读者可据此判断这类纳米反应器的递送窗口。
创新点
用EPO热分解持续产生1O2、再氧化邻近CO前体的纳米限域级联替代金属羰基CO供体，并通过EPO与3-HF结构把释放动力学调控到3个数量级，且共组装提升短寿命1O2的捕获效率。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Journal of the American Chemical Society · doi.org
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