Nature Communications·· 5 小时前精选AI 评分67
EVdesign结合理性设计改造PET水解酶，603个设计多数活性超过母本
Iterative computational and rational design generates diverse PET hydrolases for plastic depolymerization
AI 导读
研究将进化信息设计（EVdesign）与理性设计结合，改造多种PET水解酶（PETase），共实验测试来自8种母本酶的603个设计。其中400多个含12–68个氨基酸替换的变体能够解聚PET，几乎都优于母本酶，许多在部分转化率测定中接近基准LCC-ICCG的表现。
推荐理由
原文把进化信息设计与理性设计结合，用603个设计验证了PET水解酶序列改造中活性与性能方差的权衡关系。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Nature Communications · doi.org
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