Angewandte Chemie International Edition·· 4 小时前精选AI 评分62
PEtOx隐形脂质替代PEG用于无有机溶剂脂质纳米颗粒递送CRISPR-Cas9
Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations
AI 导读
研究合成以胆固醇半琥珀酸酯为脂质锚、偶联聚(2-乙基-2-噁唑啉)（PEtOx）的新型隐形脂质，作为PEG脂质的体外替代方案用于无有机溶剂脂质纳米颗粒递送CRISPR-Cas9。
推荐理由
原文对比了PEtOx与PEG隐形脂质在细胞毒性和溶血上的差异，并给出无有机溶剂LNP的体内摄取数据。
创新点
用PEtOx替代PEG作为隐形脂质亲水链，使脂质纳米颗粒可在全水相体系中制备，并在细胞毒性与溶血上明显低于PEG类似物。
来源：Angewandte Chemie International Edition · doi.org
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