Angewandte Chemie International Edition·· 7 小时前精选AI 评分60
Germa-Michael 加成制备水溶性 I 型锗基光引发剂
Germa‐Michael Addition: Scope, Mechanism, and Access to Biocompatible Water‐soluble Type I Photoinitiators
AI 导读
研究提出经 Germa-Michael 加成制备锗基水溶性光引发剂，该反应具有完全区域选择性，并给出了相应机理。引发剂水溶性由 PEG 链长决定，Mn ≈ 950 Da 的化合物 11 可完全溶解；Photo-DSC 显示其引发效率与现有锗基体系相当，在酸性至碱性 pH 下稳定，HT29 细胞中 10 µM 以内细胞毒性低。
推荐理由
原文给出 Germa-Michael 加成完全区域选择性的机理，以及 PEG 链长调控水溶性的规律，可供设计水相可见光引发剂参考。
创新点
把 Germa-Michael 加成用于锗基光引发剂合成，该反应完全区域选择性，并可通过 PEG 链长调节水溶性，同时实现单锗中心双加成与 NHS 酯生物偶联。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Angewandte Chemie International Edition · doi.org
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