Science Advances·· 7 小时前精选AI 评分58
带盖 nanovial 实现可悬浮水凝胶微腔室的大规模自组装与单细胞筛选
Massively parallel self-assembly of suspendable microcompartments for functional cell screening
AI 导读
作者提出带盖 nanovial，即把球形盖帽颗粒嵌入碗状 nanovial 自组装成水凝胶微腔室，样本中超过 80% 的 nanovial 可完成封盖，流式分选收率超过 90%。
推荐理由
带盖 nanovial 用自组装水凝胶腔室替代液滴微流控，无需油相和定制仪器即可做单细胞分泌与克隆筛选。
创新点
用盖帽颗粒嵌入碗状 nanovial 自组装出封闭水凝胶腔室，弥补了 nanovial 开放结构易丢失未贴壁或增殖细胞的缺陷，同时保留可悬浮、可流式分选的并行化优势。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Science Advances · doi.org
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