Advanced Science·· 12 小时前AI 评分40
双佐剂衰老细胞清除纳米疫苗 CK5-GC-NV 调控树突状细胞衰老并改善衰老相关代谢功能障碍
A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction
AI 导读
一种由 CpG 寡脱氧核苷酸与衰老抗原 Gpnmb 及阳离子蛛丝蛋白变体 CK5 融合蛋白共组装而成的双佐剂衰老细胞清除纳米疫苗 CK5-GC-NV，可下调 DC 中丝分裂激酶 Aurka/b 及衰老相关 PI3K/AKT 磷酸化，恢复老年 DC 的抗原交叉呈递。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Science · doi.org
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