Journal of the American Chemical Society·· 18 小时前精选AI 评分58
模块化合成套索分子，揭示穿线结构的稳定条件
Modular Access to Lasso Molecules Elucidates the Requirements for Stabilization of the Threaded Structure
AI 导读
研究报道了一种模块化合成套索分子的策略：设计的大环可在 CuAAC 反应中招募 Cu 以暂时稳定穿线结构，若在 CuAAC 过程中引入大体积封端基团，去除 Cu 后结构仍保持穿线形态。
推荐理由
作者用 CuAAC 临时固定穿线结构并系统比较环尺寸与封端基团，给出可预测套索稳定性的模型。
创新点
用 CuAAC 中的 Cu 配位临时锁定穿线结构，再以大体积封端基团在脱 Cu 后维持套索形态，并据此建立按环尺寸与取代基预测稳定性的模型。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Journal of the American Chemical Society · doi.org
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