Small·· 16 小时前AI 评分42
铈单原子光热水凝胶用于再生微环境重塑与糖尿病骨缺损修复
Multifunctional Cerium Single‐Atom Photothermal Hydrogel for Regenerative Microenvironment Remodeling and Diabetic Bone Defect Repair
AI 导读
一种整合铈单原子/聚多巴胺纳米酶与SDF-1的GelMA基多功能水凝胶被开发用于糖尿病骨缺损修复，具备近红外响应光热功能。该水凝胶可清除多种ROS、维持线粒体膜电位、减轻DNA损伤并抑制BMSC衰老，同时促使巨噬细胞向修复表型极化、增强内皮迁移与血管网络形成，并提供近红外触发的抗菌活性。在糖尿病颅骨缺损模型中，该水凝胶促进骨再生与新生血管化，并减少炎症与衰老相关信号。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Small · doi.org
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