ACS Nano·· 5 小时前精选AI 评分60
结构工程化脂质-矿物纳米粒MCP实现无配体髓系RNAi递送并改善AD小鼠病理
Structure-Engineered Lipid–Mineral Nanoparticles for Ligand-Free Myeloid RNAi Delivery in Alzheimer’s Disease
AI 导读
研究报道了一种结构工程化脂质-矿物纳米粒平台MCP，将钙磷酸盐矿物相与富含磷脂酸的脂质界面整合，实现无配体修饰的siRNA递送。MCP通过Ca2+与脂质的协同结构促进巨胞饮依赖的摄取，在体内优先递送至外周髓系细胞，尤其是Ly6Chigh单核细胞和巨噬细胞，并在AD相关炎症条件下递送增强。
推荐理由
该平台用钙磷酸盐矿物相与磷脂酸富集界面实现无配体髓系细胞RNAi递送，为外周免疫干预提供了可迁移的结构设计思路。
创新点
以钙磷酸盐矿物相与磷脂酸富集脂质界面的协同结构替代配体或抗体修饰，实现对外周髓系细胞的选择性siRNA递送，并在AD炎症条件下递送增强。
图表、补充材料与最终表述以原文为准。阅读原文
来源：ACS Nano · doi.org
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