Advanced Materials·· 15 小时前AI 评分50
幽门螺杆菌如何促进龋齿进展及双响应水凝胶 GPAM 的干预机制
Underlying Mechanisms of Helicobacter pylori in Caries Progression and the Corresponding Dual‐Responsive Hydrogel‐Based Intervention
AI 导读
幽门螺杆菌可滞留于变形链球菌生物膜内，引发变形链球菌转录重塑并提升混合生物膜致龋潜力，在大鼠龋齿模型中共定植会加重龋齿进展与口腔菌群失调。为此设计的 GPAM 水凝胶将 Cu₂O@Pt 异质结（MCP）与非晶磷酸钙（ACP）结合，在黄光与超声激活下由 MCP 产生活性氧破坏混合生物膜，释放的 Cu²⁺ 降低幽门螺杆菌脲酶活性，ACP 促进牙齿再矿化。
图表、补充材料与最终表述以原文为准。阅读原文
来源：Advanced Materials · doi.org
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