Advanced Functional Materials·· 8 小时前精选AI 评分58
可注射心肌贴附水凝胶经可逆亲和作用缓释烟酰胺核糖促进心肌修复
Localized Nicotinamide Riboside Delivery Through a Reversible Affinity Hydrogel Promotes Myocardial Restoration
AI 导读
研究团队开发了一种可注射、可贴附心肌的水凝胶，利用苯硼酸修饰壳聚糖与烟酰胺核糖（NR）之间的可逆高亲和相互作用实现NR的高效负载与缓释，以恢复梗死心肌的NAD+水平。
推荐理由
作者用苯硼酸修饰壳聚糖与NR的可逆高亲和相互作用实现小分子亲水药物的负载与缓释，为心肌梗死后NAD+补充提供了可注射贴附平台。
创新点
将苯硼酸修饰壳聚糖与NR的可逆高亲和结合引入心脏贴附水凝胶，使NAD+前体这类亲水小分子得以高效负载并在梗死心肌局部缓释。
来源：Advanced Functional Materials · doi.org
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